Cancer Prevention
Vitamin D shown to have protective effects against cancer
Higher plasma vitamin D concentrations reduce risk of several cancers
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March 2018 saw the publication of a ground-breaking Japanese study (which had followed a large number of participants since 1990) into the cancer-preventative benefits of vitamin D.[1]
While previous research into the link between circulating vitamin D concentrations and overall cancer risk in humans has yielded somewhat inconsistent results and/or was done on smaller groups (or in-vitro and on animals)[2], the present study involved 33,736 individuals. None of them had cancer (or a history of cancer) at the outset when their plasma 25-hydroxy vitamin D concentration was measured.
Over the many years of follow-up, 3,301 of these participants, both male and female, were diagnosed with cancer at some point. Comparing the respective baseline vitamin D level of all participants to their later developing cancer (or not), a link could be established between higher vitamin D levels at baseline and a lower risk of contracting cancer at a later point.
This association was particularly strong for liver cancer — in fact, higher vitamin D levels lowered hepatic cancer risk by a whopping 30 to 50%, especially in males. Even after adjustment for various dietary variables (such as total energy intake, fruit/vegetables/meat/fish consumption, and others), the association remained significant.
No association however was discovered between baseline vitamin D levels and breast, lung, or prostate cancer.
Other significant findings of the study:
- high plasma vitamin D was never correlated with a higher cancer risk
- from a certain level ("ceiling") onward, more vitamin D did not provide any additional protection against cancer.[3]
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Footnotes
1 Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort.
2 See e.g. Optimal Vitamin D Status for Colorectal Cancer Prevention: A Quantitative Meta Analysis published in the American Journal of Preventive Medicine in March 2007. The authors concluded that as little as 1000-2000 IU per day of vitamin D3 could reduce the incidence of colorectal cancer. Also see "Higher Levels of Vitamin D Linked to Lower Cancer Risk, Again" (Medscape Medical News 4/12/2016).
3 All the details regarding this study can be read at www.bmj.com/content/360/bmj.k671.long .
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